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Nafees, Sana
- Terminalia chebula Attenuates DMBA/Croton Oil-Induced Oxidative Stress and Inflammation in Swiss Albino Mouse Skin
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Authors
Ferial Majed
1,
Sana Nafees
1,
Summya Rashid
1,
Nemat Ali
1,
Syed Kazim Hasan
1,
Rashid Ali
1,
Ayaz Shahid
1,
Sarwat Sultana
1
Affiliations
1 Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, IN
1 Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 1 (2015), Pagination: 21-29Abstract
Objective: The present study was designed to investigate underlying molecular mechanism for antitumorigenic potential of Terminalia chebula (TC) against chemically-induced skin tumorigenesis in Swiss albino mice. It is used as herbal medicine because it exhibits antioxidant, anti-inflammatory, and anticarcinogenic activity. However, the précised underlying mechanism remains to be elucidated. Materials and Methods: In light of the important role of nuclear factor-kappaB (NF-κB), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS), ornithine decarboxylase (ODC), proinflammatory cytokines, oxidative stress in carcinogenesis, chemopreventive efficacy of TC against 7,12-dimethylbenz[a] anthracene (DMBA), and croton oil-induced 2-stage skin carcinogenesis was studied in terms of cytoprotective antioxidant enzymes activity, lipid peroxidation (LPO), inflammatory responses, and expression of various molecular markers in skin tissues. Results: We found that topical application of TC at dose of 30 mg/kg b. wt. mouse effectively suppressed oxidative stress and deregulated activation of inflammatory mediators and tumorigenesis. Histological findings further supported the protective effects of TC against DMBA/croton oil-induced cutaneous damage. Conclusion: The findings of the present study suggest that the chemopreventive effect of TC is associated with upregulation of endogenous cytoprotective machinery and downregulation of inflammatory mediators (inhterleukin (IL)-6, COX-2, i-NOS, ODC, and NF-κB).Keywords
Cytokines, Inflammation, Proinflammatory Markers, Terminalia chebula, Skin Carcinogenesis.- Chemopreventive Effect of Bauhinia Purpurea Against Chemically Induced Hepatocarcinogenesis via Amelioration of Oxidative Damage, Cell Proliferation and Induction of Apoptosis in Wistar Rats
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Authors
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 20, No 2 (2013), Pagination: 117-125Abstract
Objectives: In the present study we have evaluated the chemopreventive efficacy of Bauhinia purpurea against Diethylnitrosamine (DEN) initiated and 2 Acetylaminofluorine (2‑AAF) promoted hepatocarcinogenesis in Wistar rats. Materials and Methods: Efficacy of Bauhinia purpurea against 2‑AAF‑induced hepatotoxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities (reduced hepatic GSH, glutathione peroxidase, glutathione reductase, catalase, and quinone reductase), histopathological changes and expressions of early tumor markers viz., ornithine decarboxylase activity (ODC) and proliferating cell nuclear antigen (PCNA) and also expressions of p53, Bax, Bcl‑2, and caspase‑3 were evaluated. Results: Oral pretreatment with B. purpurea significantly decreased the levels of serum toxicity markers, elevated antioxidant defense enzyme activities, suppressed the expression of ODC and PCNA and P53 along with the induction of apoptosis in the pretreatment groups. Tumor incidences are reduced by pretreatment of B. purpurea. Histopathological findings revealed that B. purpurea‑pretreated groups showed marked recovery. Conclusion: The results support the protective effect of B. purpurea against chemically induced liver cancer and acts possibily by virtue of its antioxidant, antiproliferative, and apoptotic activities.Keywords
Apoptosis, Bauhinia purpurea, chemoprevention, hepatocarcinogenesis, oxidative stress- Amelioration of Renal Carcinogenesis by Bee Propolis: A Chemo Preventive Approach
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